Albenza is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. It is a broad spectrum anthelmintic, effective against: roundworms, tapeworms, and flukes of domestic animals and humans.
As a vermicidal, albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Before taking albendazole, tell your doctor or pharmacist if you are allergic to it; or to other benzimidazole anthelmintic drugs (e.g., mebendazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, biliary tract problems (e.g., blockage), blood/bone marrow disorders.
This medication may cause liver problems. Because drinking alcohol increases the risk of liver problems, limit alcoholic beverages while using this medication. Check with your doctor or pharmacist for more information.
Store between 20° and 25°C (68° and 77°F). Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Albenza out of the reach of children and away from pets.